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In accordance with this, our results showing that multiple motor features that are indicative of human dystonia are convincingly alleviated in our mouse model of dystonia support cerebellar stimulation for human therapy [63]

MITOCHONDRIAL ROS GENERATION AND DEFENSE Reactive oxygen species can be generated in several intracellular sites, including cytosol, peroxisomes, plasma membrane, and ER

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To further explore the role of the BM microenvironment in promoting mTOR activity in LTR, we analyzed mTOR expression in the non-CAR T cell fraction in the BM, which is composed of non-transduced T cells from the CAR T cell product as well as endogenous reconstituting T cells