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Keep a symptom diary noting when cold sensitivity occurs, its severity, and any associated symptoms

Common approaches include: Dietary Modifications : Reducing intake of processed and high-fat foods while increasing consumption of nutritious, high-fiber foods

Weight loss is a major accomplishment

The gallbladder plays an important role in digestion by pushing bile into the small intestines through bile ducts

For intravital imaging, PF4 Cre Thbs1 flox were bred with the ROSA mT/mG mice to obtain PF4 Cre ROSA mT/mG Thbs1 flox ( TSP1 PF4 reporter ) and PF4 Cre ROSA mT/mG Thbs1 flox ( WT reporter ) reporter mouse line