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In summary, mitophagy can reduce the risk of necrotic apoptosis caused by mitochondrial dysfunction by removing damaged mitochondria

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We also conducted RNA-sequencing of TRIP12, UBR5, or HOIP (a control, as HOIP and HOIL-1L generate M1- and Ser/Thr-linked heterotypic ubiquitin chains 35 ) knockdown cells (supplementary Fig

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