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(3) Immune Evasion: Specific oral microbes can evade host immune responses and modulate the host immune system to create a more favorable environment for their survival and colonization in the gut 61,62

Chicory root inulin and resistant potato starch are prebiotic fibers

Disruption of gut barrier integrity may facilitate the translocation of metabolites such as short-chain fatty acids (SCFAs), bile acids, tryptophan derivatives, and lipopolysaccharide (LPS), which can modulate BBB function and neuroinflammatory responses [122]

No excess of clinical cardiovascular events appeared in Phase 2, but Phase 2 was not designed or powered to detect them

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