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Contrave is not appropriate for patients with seizure disorders (bupropion lowers the seizure threshold), eating disorders such as bulimia or anorexia, current opioid use or opioid dependence (naltrexone blocks opioid receptors), uncontrolled hypertension, patients taking MAO inhibitors, or women who are pregnant or planning to become pregnant

A Although the substances in the injections may play important roles in fat metabolism, researchers are still unclear whether higher doses are beneficial for weight or fat loss and lipotropic injections may not be effective for weight or fat reduction

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