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The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria by interacting with cardiolipin

More importantly, first-pass metabolism in the liver reduces the fraction that reaches systemic circulation

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Study limitations Oral NAC is associated with gastrointestinal discomfort, nausea, and diarrhea, but these symptoms are generally mild and occur at similar rates in placebo groups, indicating that NAC is well-tolerated and safe for chronic use [108]

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