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In a pancreatic cancer mouse model, the small molecule N6-furfuryl adenine 11 (N6F11) selectively triggers GPX4 degradation in tumor cells, inducing ferroptosis

In melanocytes, depending on the type of kinase and cell line, so far it has been proven that kinases play a dual role in Nrf2 activity regulation, e.g., increased activity of JNK (c-Jun N-terminal kinase) enhances Nrf2 expression in melanocytes line PIG1 but reducing its activation PIG3V cells 69

[1] IC/BPS is associated with depression and lower quality of life

Wu, G., Fang, Y

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