Its production is primarily controlled by growth hormone (GH) (30)
We caught up with Rachel (Stratman) Wolfe, PharmD, MHA, BCCCP, FCCP at the recent Health Connect Partners (HCP) Conference and will be sharing more insights next week as we celebrate #PharmacyWeek
De novo synthesis of serine from the glycolytic intermediate 3-phosphoglycerate (3-PG) occurs through a pathway consisting of three sequential steps: phosphoglycerate dehydrogenase (PHGDH) oxidizes 3-PG to 3-phosphohydroxypyruvate (pPYR) using an NAD + cofactor, phosphoserine aminotransferase (PSAT) transaminates pPYR to phosphoserine (pSER) using glutamate as the nitrogen donor, and finally phosphoserine phosphatase (PSPH) dephosphorylates pSER to produce serine [68]
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Hypothetically, this structure allows AOD-9604 to burn fat without the unpleasant side effects that can come with full-length GH, like joint pain, fluid retention, or blood sugar changes
