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What GLP1s are and how they work GLP-1s, also known as GLP-1 receptor agonists, are medications designed to mimic action of glucagon-like peptide-1 (GLP-1), a hormone the body naturally releases after eating

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[15] [16] Constipation paradoxically affects 10-20% of patients, demonstrating that GLP-1 medications can slow bowel transit to varying degrees in different individuals