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Topical tretinoin improves photoaged skin: A double-blind vehicle-controlled study

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In controlled lab models, researchers have observed changes in fibroblast behavior when these cells are exposed to the peptide, including shifts in signaling activity tied to tissue structure

Life Sci 88(1112):535542 Ilic S, Drmic D, Zarkovic K et al (2011b) Ibuprofen hepatic encephalopathy, hepatomegaly, gastric lesion and gastric pentadecapeptide BPC 157 in rats

As a result, local inflammation develops, and activated immune cells and cytokines can affect other organs or trigger immune-related diseases, e.g., autoimmunity