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Because treatment was not randomly assigned, the result is an association that strengthens the case for testing metformins impact on healthspan rather than proof that the drug extends life

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Patients with diabetes who remained on GLP-1 drugs had lower cardiovascular risk March 25, 2026 Summary: Continuous use of GLP-1 drugs in patients with type 2 diabetes is associated with significantly lower rates of cardiovascular events and death compared to discontinuation or intermittent use

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