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By interrupting a key proteinprotein interaction that allows senescent cells to persist, FOXO4-DRI offers the potential to selectively eliminate those cells and thus improve tissue function, reduce inflammation, and restore aspects of youthful physiology

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However, its specific mechanisms in DOR remain unclear

Further support comes from cross-sectional studies comparing PD and matched control subjects 13 , while others have investigated the role of UA in disease progression and severity, with findings suggesting an influence of low UA in each of these clinical factors 14,15

[DOI] [PMC free article] [PubMed] [Google Scholar] 47.Booty L.M., King M.S., Thangaratnarajah C., Majd H., James A.M., Kunji E.R.S., Murphy M.P