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[7] Symptom onset 6 months prior The presence of 2 of the following symptoms in at least 25% of bowel movements over the last 3 months: Passage of spontaneous stool 50 years if age-appropriate colorectal cancer screening has not been performed

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Indeed, it is suggested that NOSs are capable to generate O 2 in Ca 2+ dependent manner particularly in case of absence of substrate, Larginine and cofactor H4B, both of which being associated with the diabetes [7]