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Interestingly, the incubation with the antioxidant N-acetylcysteine (NAC) upon treatment with NP4 resulted in reduced levels of apoptosis, suggestive that the cytotoxicity of NP4 is related to intracellular redox homeostasis (Supplementary Fig

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109,110 Additionally, antioxidants including vitamins A and C, CoQ10, and -lipoic acid have been suggested to improve behavioral parameters and reduce oxidative stress, mitochondrial dysfunction, and glutamate-induced toxicity in PD