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The study was described as the first to demonstrate that FOXO4-DRI activates the p53/BCL-2/Caspase-3 pathway specifically in senescent endothelial cells

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Successful CagriSema dosing requires following proven titration schedules - both peptides escalating over 13-17 weeks to 2.4mg weekly each - with proactive side effect management during the critical weeks 9-16 when nausea peaks

(PubMed) Frei B, Birlouez-Aragon I, Lykkesfeldt J