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The application is supported by the Phase 3 TIGRIS trial, which met its primary endpoint and demonstrated sustained survival benefit through 12 months, adding to the growing body of clinical evidence evaluating PMX in patients with endotoxic septic shock identified using the FDA-cleared Endotoxin Activity Assay (EAA)
CrossRef Correspondence to editorial on Switching to besifovir in patients with chronic hepatitis B receiving tenofovir disoproxil fumarate: A randomized trial Hyung Joon Yim, Seong Hee Kang, Young Kul Jung, Jin Mo Yang Clinical and Molecular Hepatology .2026
And here is the important part: if you miss two or more consecutive doses, you may need to restart the full titration schedule from 0.25 mg to avoid severe gastrointestinal side effects