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Visceral adipose tissue is the type of fat that accumulates around the organs in the abdominal cavity and is associated with an increased risk of metabolic diseases such as type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease

The STEP 1 trial (Wilding et al., N Engl J Med, 2021) documented nausea in 44.2% of participants at the 2.4 mg dose versus 17.4% on placebo

This pause matters pulling out early can let part of the dose leak back out

At the maintenance dose of 2.4mg per week, a 5mg vial lasts roughly two weeks

By improving systemic insulin sensitivity, semaglutide also attenuates adipose tissue lipolysis, thereby lowering the circulation of free fatty acids (FFAs) that would otherwise be delivered to the liver for TG synthesis [16]