CDC 2015a
When the gut lining is inflamed and permeable, neurotransmitter production is disrupted, inflammatory cytokines cross into systemic circulation and reach the brain, and the vagus nerve the primary communication cable between gut and brain transmits distress signals that manifest as anxiety, brain fog, and fatigue
2 Materials and methods 2.1 Drugs and reagents Ketamine (Vetased R , Pasteur, Romania), Thiopental, Ethylenediaminetetraacetic acid (EDTA), thiobarbituric acid (TBA), 1,1,3,3-tetraethoxypropane (TEP), vanadium (III) chloride (VCL3), sulfanilamide, N-(1-Naphthyl) ethylenediamine dihydrochloride (NEDD), sodium nitrite (NaNO2), 2,4-dinitrophenylhydrazine (DNPH), trichloroacetic acid (TCA), guanidine hydrochloride, 5,5-Dithiobis-2-nitrobenzoic acid (DNTB)
Diabetes Care 39 Suppl 1, S4-5, (2016)
Folate and folic acid are converted to tetrahydrofolic acid (THF) in the body to contribute to methylation pathways (67)