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Thus, the high concentrations of GSH observed during autumn, compared with those observed during the other seasons, could have increased to achieve an oxidative balance and physiologically counteract the high production of ROS

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Moreover, oxidation of AAT may lead to a loss of its anti-protease activity that is already lower in AATD, so the antioxidant potential in the treatment of emphysema patients with AATD needs to be considered

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