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& Rajagopalan, S

To think of this as a quick fix that there is this medication that'll lead to weight loss and then it's done I think is a misunderstanding of the problem as a whole, says Simonetti

By stimulating these receptors, these medications help create a feeling of fullness, slow down digestion, and stabilize blood sugar levelsall essential factors for effective weight loss

SURMOUNT-1 Trial Tirzepatide Once Weekly for the Treatment of Obesity (NEJM, 2022) 7

Observational research presented in March 2026 at the American Academy of Orthopaedic Surgeons annual meeting found that GLP-1 drugs may slightly increase the risk of developing osteoporosis and gout, a kind of inflammatory arthritis caused by a buildup of uric acid