[DOI] [PMC free article] [PubMed] [Google Scholar] 166.Almekkawi A.K., AlJardali M.W., Daadaa H.M., Lane A.L., Worner A.R., Karim M.A., Scheck A.C., Frye R.E
Driving and inhibiting ferroptotic mechanisms Ferroptosis, a type of non-apoptotic cell death, is characterized by three main processes that affect the sensitivity of cells to ferroptosis: (1) an increase in the content of free iron that generates ROS through the Fenton reaction, (2) a depletion of the antioxidant glutathione (GSH) and a loss of glutathione peroxidase 4 (GPX4) activity, and (3) an accumulation of lipid peroxidation products and a disruption of cell membranes [12]
Her accolades as one of America's Best Family Physicians assure you of quality care from an award-winning expert
Best For Dark spots, age spots, and hyperpigmentation Uneven and dull skin tone Skin needing brightening and repair
10.3945/jn.116.230912 [DOI] [PubMed] [Google Scholar] 293.Bharath LP, Nikolajczyk BS