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Overall, the MD data was consistent with the markedly different dynamics observed in the cryo-EM 3DVA with the ECDs undergoing substantially greater dynamic motions in the Cagri-AMY 3 R complex than observed in the parallel rAmy-AMY 3 R complex (Supplementary Fig

65 However, different isomers react differently to ROS, and the sensitivity of BCAT 2 is many orders of magnitude higher than that of BCAT 1

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Gastrointestinal adverse events were common (79.6% vs

This energy deficit leaves the cell vulnerable to further oxidative damage, creating a vicious cycle of depletion and dysfunction that is incredibly difficult to break without targeted nutritional support