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this information could be coupled to other biomarkers of disease, informing patients on their risk for disease as well as the potential severity or progression

202,203 In vivo, astrocytes are more sensitive to periods of ischaemia, although they still tolerate them better than neurones

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Research has also demonstrated that metformin increases the abundance of Akkermansia muciniphila in the gut, which triggers the transcription of host antioxidant genes, including Nqo1 , Ho-1 , and Gpx4 [17]

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