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In view of these reported differences in effects of Cannabis sativa as regards depression, the aim of the study was to: (1) examine the effect of cannabis in the forced-swim test (a test for depressive-like behavior) (Porsolt et al., 1978) in normal mice and after treatment with the selective serotonin reuptake inhibitors (SSRIs) fluoxetine and sertraline as well as the tri-cyclic drug imipramine with view to a possible modulatory effect of antidepressant drugs

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Studies also showed that THC strongly affects rearing activity more strongly than locomotion with tolerance being evident to the latter, but with no recovery of the reduced rearing activity when exposure to THC was continued for weeks (Miczek and Dixit, 1980

In addition, it was reported that phosphorylation of Nrf2 by GSK-3 pathway could lead to Nrf2 nuclear transportation and degradation [4143]