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Moreover, the AR signaling axis can activate GLS activity, promoting the conversion of glutamine to glutamate and providing energy substrates for the tricarboxylic acid cycle, another potential mechanism for the use of metabolic inhibitors in combination with ADT

As previously mentioned, the reaction of superoxide radicals with nitric oxide reduces NO bioavailability, leading to impaired endothelium-dependent vasodilation

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The biosimilar entry timeline may be shorter, the price erosion faster, and the ability to use the patent dance to delay entry more constrained given increased PTAB experience with biologic patent challenges