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Animal studies using the gold-standard euglycemic clamp technique confirmed that even chronic AOD-9604 treatment produced no adverse effects on insulin sensitivity, despite significant fat loss occurring

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In addition, future work is required in order to elucidate the specific dynamics of ROS and in particular H 2 O 2 , including the movement of H 2 O 2 and its interplay with specific AQPs and gap junctions, or the role of ROS and other ROS-producing organelles such as the ER, which play important roles in wound healing and may potentially be targeted through pre-clinical agents 194