Contraindications Retatrutide is not appropriate for people with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia type 2 (MEN-2), or those with a history of pancreatitis
However, in a study by Bezin and colleagues (2023), the use of GLP-1 RA for 1-3 years was associated with an increased risk of thyroid cancer and medullary thyroid cancer
Bifidobacterium breve BBr60, by remodeling the gut microbiota-SCFAs axis, inhibits the pro-inflammatory factor IL-1, activates the anti-inflammatory signal IL-27, and synergistically regulates the metabolic hormone network (such as GLP-1, ADPN), significantly improving obesity-related metabolic disorders
The presence of excessive lipid buildup leading to enhanced production of adipose tissue-derived mediators and factors can promote inflammation (66)
Inflammation-responsive nanoparticles suppress lymphatic clearance for prolonged arthritis therapy
