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Continuous GLP-1 exposure triggers changes in insulin sensitivity and blood sugar regulation

The metabolic benefits of GLP-1 therapy extend well beyond weight loss, including beta-cell preservation, improved insulin sensitivity, and cardiovascular risk reduction

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This accessibility factor often translates to longer treatment durations in practice, which may partly explain why week-by-week results in real-world settings sometimes exceed clinical trial averages

For example, in the STEP 1 trial extension, patients who stopped semaglutide after 68 weeks of treatment regained about two thirds of the weight they had lost within one year of discontinuation