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A double-blind multicenter comparison of domperidone and metoclopramide in the treatment of diabetic patients with symptoms of gastroparesis

According to FDA prescribing information, nausea rates vary by indication and dosageapproximately 15-20% of patients taking semaglutide for diabetes management experience nausea, while rates increase to up to 44% for those on higher doses for weight management

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Recently, researchers developed a translational pharmacokinetic and pharmacodynamic model by integrating in vitro and in vivo data in a mechanistic and quantitative manner, which revealed a dose-dependent reduction in the cardiac amyloid burdenoccurring within 4 months at 60 mg/kg and within 10 months at 10 mg/kg