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de Oliveira RodriguesSCoeli da CunhaCMVallado SoaresGMLeme SilvaPRibeiro SilvaAGonalves-de-AlbuquerqueCF

Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

Glutathione protects our cells delicate chemical machinery, and helps energy metabolism run efficiently.* Glutathione is also integral to our immune system, especially for resistance to viruses.* Typical oral delivery of glutathione is greatly inhibited by breakdown in the stomach

Levodopa, the most potent symptomatic therapy, markedly improves motor symptoms, yet it comes with considerable adverse reactions ( As early as 1982, glutathione peroxidase 4 (GPX4) was reported to inhibit the accumulation of lipid hydroperoxides, thus preventing plasma membrane damage ( - system) and shared several characteristics with ferroptosis, including reactive oxygen species (ROS) accumulation and high lipoxygenase enzymatic activity ( - system overexpression ( Figure 1 )