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doi: 10.1038/s41422-018-0090-y 48

These serious side effects may involve an increased heart rate, kidney failure, severe allergic reactions and other kidney-related problems, hypoglycemia, pancreatitis, gallbladder issues, depression, and thoughts of suicide

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"Some people can carry visceral fat, but tolerate it well and have no metabolic effects that's uncommon." For most people, extra "toxic" mid-section fat, which is not always visible, "can ultimately make you not feel quite as good." Once the negative signaling from that extra visceral fat is gone, a whole chain of health benefits can ensue, he said