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The individual agents differ in their unique pharmacology such as half-life and degree of structural homology to GLP-1 [39]

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Olympus, Tokyo, Japan) and continuously superfused at a flow speed of 1 mL/min with a bath solution containing 140 mM NaCl, 5 mM KCl, 1 mM CaCl 2 , 2 mM MgCl 2 , 10 mM HEPES, and 10 mM glucose, adjusted to pH 7.4 with NaOH

To enroll, one of the following must apply: BMI 27 and an obesity-related comorbid condition BMI 30 with or without comorbid condition Obesity-related comorbid conditions include but are not limited to diabetes, prediabetes, hypertension, dyslipidemia, CAD, osteoarthritis, and obstructive sleep apnea