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Ammonia levels rapidly decreased within 10 hours (to 35 mol/l), the neurological condition improved and triphasic waves on the electroencephalogram disappeared

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The activated Trem2 signal in stage 1 DAM facilitates transition to stage 2 DAM, which is characterized by an upregulation of lysosomal, phagocytic, and lipid metabolism pathway-related genes including cst7 and itgax

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doi: 10.1038/ni.3577 65 HochreinSMWuHEcksteinMArrigoniLHermanJSSchumacherFet al

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