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Aperu de la recherche en matire de scurit De nombreuses tudes toxicologiques et des essais cliniques ont tabli que le glutathion topique est gnralement reconnu comme sr (GRAS) pour un usage cosmtique

16 August 2016

F.TangY

Intranasal administration of the optimized formulation (Cmax = ~ 600 ng/mL, tmax = 0.5 h) exhibited a plasma AUC 0.78 times the AUC of the orally administered product (Cmax = ~ 780 ng/mL, tmax = 2 h), whereas the brain AUC was significantly (3.28 times) higher for intranasal administration (Cmax = ~1240 ng/mL, tmax = 0.5 h) than oral administration (Cmax = ~ 380 ng/mL, tmax = 1 h)

Robberecht and Philips, 2013