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By clearing these cells, FOXO4-DRI reduces inflammation and restores tissue function, potentially mitigating age-related decline and promoting healthier aging

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In these cells, the transcription factor FOXO4 is highly upregulated and physically sequesters the tumor suppressor p53 in nuclear foci, preventing p53 from triggering apoptosis

The condition is characterized by elevated anti-thyroid peroxidase (anti-TPO) and anti-thyroglobulin antibodies, lymphocytic infiltration of thyroid tissue, and gradual development of hypothyroidism