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Potential risks include compounded gastrointestinal side effects, unpredictable effects on blood glucose levels, and unknown interactions due to variable supplement composition

The GLP-1R agonist exendin-4 was shown to promote neurogenesis in the subventricular zone region in a neurodegenerative disease rodent model (Bertilsson et al., 2008)

Results GLP-1R trafficking controls pharmacological insulin release Interaction between the surface regions of receptor transmembrane helices and the agonist N-terminus is critical for the activation of class B GPCRs, including the GLP-1R 20

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However, there is a notable difference in the amount of research using GHK-Cu topical vs injection delivery methods