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Discussion This study illustrates that real-world data (RWD) and randomized controlled trial (RCT) datasets, derived from patients with diabetic chronic kidney disease, share common characteristics but also exhibit substantial differences in terms of data generation, completeness, and temporal dynamics

Understanding how DSIP influences biological clocks helps researchers explore mechanisms behind jet lag, shift work fatigue, and disrupted sleep cycles

ClinicalTrials.gov registry entry NCT05669755 (2025) 8

contrastingly, PARP-1 treatment promoted PARP-1 phosphorylation while it decreased ABCA1 protein level upon cholesterol stimulation