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We believe the mechanism of effect is on calcium channels, and that can reduce transmission of those abnormal nerve signals, often within the peripheral nerve or the spinal cord, says Williams

These findings, they said, supported the use of semaglutide, on top of usual care, to reduce the risk of major adverse cardiac events in a broad population of people with established atherosclerotic cardiovascular disease and overweight/obesity

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However, interpretation is subject to similar concerns about confounding, bias and data quality, and there is a need for validation by higher-quality prospective studies