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Inhibition of miR-19b-3p expression, which facilitates ferroptosis by targeting SLC7A11, has shown benefit effects on chondrocytes against ferroptosis in OA [92]

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[25] A two-week study of 203 obese patients hinted that Tesofensine could have the ability to reduce weight two times more than any weight-loss drug currently on the market

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Melatonin, known for its antioxidant properties, also modulates the Nrf2 pathway, enhancing the expression of heme oxygenase-1 (HO-1), which strengthens antioxidant defenses in DN ( Radix Hedysari , ameliorated DPN by activating the Keap1/Nrf2 signaling pathway, further supporting the role of Nrf2 activation in managing OS-related complications in diabetes ( 4.6.2 NF-B pathway The NF-B pathway plays a significant role in the inflammatory processes associated with DN