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Beyond these classical mechanisms, bilirubin may fundamentally shape PD risk by orchestrating early embryonic development of dopaminergic neurons through key morphogenic signals, thereby ensuring robust neural circuit formation

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For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients

Conclusion In conclusion, the present study demonstrates that children with ASD exhibit distinct but subtle plasma metabolomic features , particularly involving branched-chain amino acid metabolism, methyl-donor pathways, and diet-responsive bioactive compounds

PMID: 25002025