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Under pathological conditions, abnormally aggregated -syn can significantly suppress autophagic activity through multiple mechanisms, including interfering with the Bcl2-BECN1 complex, inhibiting Rab1a function, and disrupting lysosomal homeostasis

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In conclusion, anxiety, PTSD, and depression are common comorbidities in veterans who suffer from GWI, and these psychiatric symptoms may improve by following the low glutamate diet