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Mammalian PK has four isoforms with distinct tissue distributions, PKM1 is predominantly expressed in normal adult cells favoring oxidative phosphorylation, while PKM2 is highly expressed in rapidly proliferating tumor and non-malignant cells, favoring glycolysis ( Lactate dehydrogenase (LDH) has gained increasing attention for its significance in cancer

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Antioxidants help protect cells from free radical damage ( Free radicals are highly volatile, cell-damaging chemicals that are a byproduct of normal human metabolism

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