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And there is growing recognition that unmanaged demand, not just drug price, is one of the biggest long-term risks

Thomson, A.D

Topamax and phentermine-topiramate have different main active ingredients and FDA-approved uses: The main active ingredient in Topamax is topiramate

Its primary physiological effects include: Glucose-dependent stimulation of insulin secretion Suppression of glucagon release Slowing of gastric emptying Promotion of satiety via central nervous system pathways GLP-1 receptors are expressed in multiple tissues, including: Pancreatic beta cells Gastric smooth muscle The hypothalamus Vagal afferent pathways Cardiovascular tissue Under normal physiology, endogenous GLP-1 has a very short half-life (approximately 12 minutes), as it is rapidly degraded by dipeptidyl peptidase-4 (DPP-4)

G (00:54:51): So there's two ways to do that