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Rosacea, poor sleep quality, and obstructive sleep apnea: A commentary on potential interconnected features

Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

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PubMed Kleinert, M., Sachs, S., Habegger, K.M., Hofmann, S.M., & Mller, T.D