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Notably, Through a feedback mechanism, mTORC1 inhibition may momentarily increase mTORC2 signaling, causing temporary metabolic disruptions during the first phase of treatment (224), which can transiently disrupt metabolism and frequently leads to hyperlipidemia, necessitating concomitant lipid-lowering therapy (237239)

Zhuo M, Small SA, Kandel ER, Hawkins RD

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Louis, MO, United States), and trypsin from Roche Diagnostics (Mannheim, Germany)

Minimizing side effects Most DSIP side effects result from excessive dosing