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Deficiency of folate with or without vitamin B12 deficiency impairs DNA synthesis, leading to cell death, ineffective red blood cell production, and anemia

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Vitamin Supplements Other Than Vitamin C Although deficiencies of vitamin B 12 and folate are recognized causes of anemia and rarely are the basis for ESA hyporesponsiveness, there are no RCTs showing that supplementation with vitamin B 12 , folate, or other vitamins (in the absence of documented vitamin deficiency) is an effective adjuvant to ESA therapy