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The dysesthesia signal in retatrutide, while mild, is an example of a novel side effect that wasn't seen with simpler agonists

Ozempic tends to lower fasting numbers by 25-30 mg/dL on average, while Trulicity typically achieves 20-25 mg/dL reductions

The only way to know your best option is a consultation and labs

The 2022 ADA/EASD consensus report notes that "the magnitude of gastric emptying delay with once-weekly GLP-1 RAs is clinically smaller than with short-acting formulations, but it is not zero" [4]

These metabolic improvements may contribute to overall cardiovascular health rather than causing cardiac damage