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( 2.3 Long-term and real-world evidence Long-term evidence from selected studies, highlights the sustained clinical benefits of liraglutide and semaglutide ( A number of studies provided compelling evidence that liraglutide significantly improved PASI scores, CRP levels, and VAS pain in obese patients with PsO, regardless of weight loss, highlighting the direct immunomodulatory role of GLP-1Ras ( Finally, in a large scale retrospective cohort study by Sontam et al

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Common indications include: Pernicious anaemia an autoimmune condition where the stomach cannot produce intrinsic factor, a protein necessary for B12 absorption [8] [9] Malabsorption disorders including Crohn's disease, coeliac disease, or following gastric surgery Strict vegan or vegetarian diets with confirmed deficiency though high-dose oral B12 may be sufficient if no malabsorption exists Certain medications such as metformin or proton pump inhibitors that may interfere with B12 absorption [9] [10] Neurological symptoms including peripheral neuropathy, memory problems, or balance difficulties related to deficiency Diagnosis should be confirmed through blood tests measuring serum B12 levels, full blood count, folate, and often anti-intrinsic factor antibodies