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GLP-1 receptors in the intestine shift fluid and electrolyte handling and can speed colonic transit, even while the stomach empties more slowly

and even as they account for less than 1% of the intestinal epithelium, they establish a complex signaling network, that is likely to be the first step of integration, involving the information obtained from the gut lumen (63, 88, 89)

(PubMed) Larsson SC, Orsini N, Wolk A

Brain Signaling: GLP-1 RAs interact with receptors in specific areas of the brain, particularly the hypothalamus, which acts as the control center for hunger and satiety