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GWAS for the HGA/GR ratio identified two genetic loci that mapped to the TAC1 and ASNS genes, which are known to be involved in depression and neurotransmission, while the ratio MET/TYR identified the gene AGBL1 previously linked to neurodegeneration in mice

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iii) driving and/or recurrent genomic changes ( Table 2 The WHO 2018 classification of melanoma according to pathways